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use (Z72.0) Excludes1: chronic bronchitis NOS (J42) chronic obstructive bronchitis (J44.-) J41.0 Simple chronic bronchitis J41.1 Mucopurulent chronic bronchitis J41.8 Mixed simple and mucopurulent chronic bronchitis J42 Unspecified chronic bronchitis Includes: chronic bronchitis NOS chronic tracheitis chronic tracheobronchitis Use additional code to identify: exposure to environmental tobacco smoke (Z77.22) exposure to tobacco smoke in the perinatal period (P96.81) history of tobacco use (Z87.891) occupational exposure to environmental tobacco smoke (Z57.31) tobacco dependence (F17.-) tobacco use (Z72.0) Excludes1: chronic asthmatic bronchitis (J44.-) chronic bronchitis with airways obstruction (J44.-) chronic emphysematous bronchitis (J44.-) chronic obstructive pulmonary disease NOS (J44.9) simple and mucopurulent chronic bronchitis (J41.-) J43 Emphysema Use additional code to identify: exposure to environmental tobacco smoke (Z77.22) history of tobacco use (Z87.891) occupational exposure to environmental tobacco smoke (Z57.31) tobacco dependence (F17.-) tobacco use (Z72.0) Excludes1: compensatory emphysema (J98.3) emphysema due to inhalation of chemicals, gases, fumes or vapors (J68.4) emphysema with chronic (obstructive) bronchitis (J44.-) emphysematous (obstructive) bronchitis (J44.-) interstitial emphysema (J98.2) mediastinal emphysema (J98.2) neonatal interstitial emphysema (P25.0) surgical (subcutaneous) emphysema (T81.82) traumatic subcutaneous emphysema (T79.7) J43.0 Unilateral pulmonary emphysema [MacLeod's syndrome] Swyer-James syndrome Unilateral emphysema Unilateral hyperlucent lung Unilateral pulmonary artery functional hypoplasia Unilateral transparency of lung J43.

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Microsomal prostaglandin E synthetase-1 gene (mPGES-1) and the PGE2 produced in the spleen are the key factors connecting the immune and nervous systems affected by nicotine (Revathikumar et al., 2018)