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KRAS(G12C) inhibition with sotorasib in advanced solid tumors

KL: Methodology, Funding acquisition, Writingreview and editing, Supervision, Conceptualization

In addition to directly activating p53, the excessive UVR-induced ROS activate JNK and p38 MAPK, which mediate p53 activation with upregulation of target genes exhibiting a pro-oxidant role such as BAX , the tumor protein p53 inducible protein 3 ( TP53I3 or PIG3 ), PUMA , and PMAIP1 (encoding NOXA) [60]

FIGURE 4 Overexpression of miR-34a-5p attenuates harmful effects of maternal smoking on APAP-induced ALI in offspring mice We next evaluated the influence of reduced hepatic miR-34a-5p expression resulting from prenatal exposure to MSCS on APAP-induced hepatotoxicity in the offspring

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