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Although one meta-analysis of earlier randomized trials had reported an increased risk of CVD events among smokers using varenicline,(137) subsequent larger meta-analyses(129,138140) and several large retrospective cohort studies(141143) found no evidence of a significantly increased CVD risk with varenicline use

PMID 30477337

Study results showed individuals reporting dual use did not differ from those reporting exclusive use of combustible cigarettes per day or CPD (13.1 vs

In 2020, according to the World Health Organization (WHO), 21.7% of the worlds population aged 15 years or older used tobacco: 35.5% of men and 7.9% of women

Nicotine Replacement Therapy This would include e-cigarettes, dermal patches, nicotine gums, or any other form of tobacco-less nicotine supplement