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Song, Q., Baxter, G
Some examples of p53-activated ROS-detoxifying molecules reported in an UVR context are depicted in Figure 3, including the enzymes manganese superoxide dismutase 2, SOD2 [49], glutathione peroxidase 1, GPx1 [50], peroxiredoxin, PRDX1 [51], and NAD(P)H quinone dehydrogenase 1 (NQO1) [52]
Indeed, TP53 point mutations have been identified in approximately 60% of actinic keratoses and 5090% of cSCCs [96], mainly occurring in DNA-binding domain (DBD) clustering at several hotspot amino-acid residues [23,24]
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Casal-Mourino A, Ruano-Ravina A, Torres-Duran M, Parente-Lamelas I, Provencio-Pulla M, Castro-Anon O, et al
