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Wellbutrin (bupropion), an antidepressant also used for smoking cessation, works by blocking dopamine absorption in the brain, which can reduce the rewarding effects of smoking

Investments have been made in the development of NAMs for assessing endpoints of relevance to TNCPs, as well as in the development of adverse outcome pathways that demonstrate the biological relevance of the NAMs

But the agency still needed scientific evidence to back up taking action

World No Tobacco Day 2026 World Health Organization

"Justice Department attorneys have worked diligently for over 20 years to hold accountable the tobacco companies that defrauded consumers about the health risks of smoking," said Associate Attorney General Vanita Gupta in a statement