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In fact, studies show that smokers develop two to three times more facial wrinkles than non-smokers of the same age

Circulation 96:32433247 Rao P, Ande A, Sinha N, Kumar A, Kumar S (2006) Effects of cigarette smoke condensate on oxidative stress, apoptotic cell death, and HIV replication in human monocytic cells

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For a sub-group of drugs, exposure estimation based on sewage analysis is available (Table 2) (not all drugs are available in sewage analysis due to different stabilities/degradation rates of the compounds, for details see Ref