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The American Heart Association reports that carboxyhemoglobin levels in smokers often exceed 5%, while the norm is below 1.5% (American Heart Association, 2023)

Effective Date: October 24, 2024 Recommendations and Topics Scope Background Epidemology Screening and Brief Intervention Pharmacological Management of TUD Special Populations Vaping Use Controversies in Care Appendices References Scope This guideline provides evidence-based recommendations for primary care practitioners on managing tobacco use disorder (TUD)

Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons

However, although this final category is not generally considered a harm reduction approach, we suggest it fits logically within a harm reduction framework
