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An artefactual reason for why the smoking-mortality association may vary is increased confounding over time as smoking becomes more strongly patterned by socioeconomic position (SEP), passive smoking 11 and other behaviours (eg, diet) that are independently associated with mortality

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Moreover, males who smoke also had 13% higher free testosterone levels , and a larger number of cigarettes per day correlated with bigger T

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Compared with not smoking, the adjusted relative risk of developing schizophrenia associated with smoking more than 10 cigarettes per day was 2.28 times higher (95% CI = 1.194.34) and was statistically significant (Weiser Reference Weiser, Reichenberg and Grotto2004)