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The FDA does not regulate e-cigarettes and does not consider them to be a safe nicotine delivery system or cessation product

For retailers (such as tobacco-only stores or vape stores) that have as its primary purpose the sale of tobacco products, alternative nicotine products, or both, it is unlawful for a person under eighteen years of age to enter the store, unless the minor is actively supervised and accompanied by an adult

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Those studies suggested that CC and EC impaired the phagocytic activity of granulocytes and monocytes, contributing to bacterial colonization and increased pathogen burden in the respiratory mucosa, factors that might associate with dysbiosis of the lung microbiome, poor airway health and increased infections in COPD patients [37,38,39,40,41]