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In three separate but related studies, interleukin-6 [IL-6], keratinocyte growth factor-1 (KGF-1) and insulin-like growth factor-1 (IGF-1) expressions, which have all been implicated in tissue fibrogenesis, were significantly upregulated in persons with OSF due to BQ chewing and arecoline may be responsible for their enhanced expression [40][42]

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