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Filter ventilation reduced not only tar and nicotine yields, but by diluting the smoke gases, it also reduced carbon monoxide yields at least when measured by smoking machines

Another study found that NRT use significantly decreased the risk of preterm delivery and low birth weight compared to smokers and found that NRT use does not appear to increase the risk of malformations

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Together, this dramatically increases the chance of a clot forming in a vein (deep vein thrombosis, DVT) or traveling to the lungs (pulmonary embolism, PE)