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While Nicotine is the main addictive substance in tobacco smoke, many major smoking-related diseases are associated with toxicants produced by combustion, including carbon monoxide and carcinogenic compounds in smoke

As illustrated in Figure 4, minor positional deviations can lead to considerable changes in IoU

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This applies not only to water or shampoo, but also to creams, gels, pastes, aerosols, and many cosmetic products

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