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When the FTND PGS was the sole predictor, it was associated with all 4 FTND items and 9 of 11 DSM criteria (Figure 3b), as well as the total number of endorsed DSM-5 TUD criteria ( = 0.118, SE = 0.025, p FDR = 7.2e6, variance explained = 0.2%) and total number of endorsed FTND items ( = 0.052, SE = 0.010, p FDR = 1.3e6, variance explained = 0.2%