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PrEP, short for Pre-Exposure Prophylaxis, was initially introduced as a preventive measure against HIV and has since proven to be a groundbreaking tool in preventing HIV for those at high risk of contracting it

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Alleles S and Z encode abnormal proteins that polymerize in the liver, and therefore, 80-90% of PiZ and 40-50% of PiS molecules are retained inside the hepatocyte-forming polymers, usually degraded by the proteasome