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Abbreviations BC: breast cancer TAM: tumor-associated macrophages CCL5: C-C motif chemokine ligand 5 CCR1/3: chemokine receptor 1/3 VCAM-1: vascular cell adhesion molecule 1 E-cig: E-cigarettes CS: cigarette smoking MMPs: matrix metalloproteinases VEGF: vascular endothelial growth factor TNF: tumor necrosis factor EVC: E-cigarette vapor condesate Declarations Acknowledgement None

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Figure 1 Flowchart for article selection The articles were published between 20042019, eight were cross-sectional 21,26-32 , and the other nine studies were prospective studies 17,18,33-39
