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Further animal and human studies have shown that different efficacy at 5-HT2A receptors is a key pharmacological mechanism responsible for the psychedelic effects [22,23,24] and that different psychedelic substances also have affinities for other receptors: serotonergic, dopaminergic, glutamatergic, adrenergic, and histaminergic [25,26,27,28]

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[3][5][6] If nicotine is ingested at low doses, it can make you feel alert, but it overwhelms the body at high dosages, causing adverse effects