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Considering that hepatocytes are accounted for glucolipid metabolism, the normal hepatocyte program could be disturbed by glucose and lipid metabolism disorder (Fig

The p53 target p21 competes with Keap1 for Nrf2 binding, resulting ultimately in a stable and activated Nrf2 that upregulates the expression of several genes through binding to AREs [54]

[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Bell H.S., Dufes C., OPrey J., Crighton D., Bergamaschi D., Lu X., Schtzlein A.G., Vousden K.H., Ryan K.M

You can get duplicates this way, by any spares you have can be offloaded to a Fence

Mechanistically, we found that overexpression of miR-34a-5p significantly reduced protein levels of HNF4 and CYP3A11, leading to a decrease in the severity of APAP-induced ALI