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It is plausible, that DCs can adopt Th-1 promoting function, which is necessary to fight infections, only when the balance of environmental signals strongly favors Th1 immunity, and promote Th2 response in a Th2-biased environment, which primes the development and exacerbation of asthma [246]
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It has been shown that the application of nicotine on the tongue modifies the response of the neurons in the nucleus of the solitary tract of rats 13
A proposed algorithm for the approach to the management of IBD in smokers is proposed based on this review (Fig
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