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There have been questions as to whether varenicline can cause symptoms of depression, suicidal thoughts, agitation, and aggression, though research suggests that while all of these problems can occur when people try to quit smoking, none of them occur more frequently among people taking varenicline than those assigned placebo

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Over this period, pouches of 30 grams also saw a large, rapid decline, from 24% in 2013 to no pouches among the most popular brands in 2020 or 2022