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First, after strong industry opposition to a RAND Europe study that provided the baseline for the Commission's IA,61 DG-SANCO commissioned two further studies,62 ,63 which had not been anticipated in the official roadmap.60 Second, DG-SANCO's public consultation on the Directive attracted over 85 000 submissions, more than any other EU consultation

did not meet the Healthy People 2010 goal of 12% adult smoking prevalence until year 2021 1,45

Family history of premature cardiovascular disease is a key risk factor that can nearly double the risk of cardiovascular events 6,51 , but we were unable to adjust for this information or other genetic determinants of cardiovascular risk in our multivariate model

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