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Selected brands also introduced filter ventilation and reduced weight, which act to reduce harshness and increase perceived smoothness.22 23 Synthetic coolants, such as WS-3, can exert similar cooling effects as menthol by binding to the same cellular receptors (TRPM8 and TRPA1).24 For some coolants, including WS-3, the relative agonistic potency is greater, producing more intense lingering cooling effects.25 Notably, an estimated 1200 synthetic coolants have been developed to mimic, intensify or prolong cooling effects compared with menthol.25 26 While our results did not identify additional synthetic coolants, manufacturers may continue modifying ingredient lists in place of menthol bans

Lancet 394:1297 Thun MJ, Freedman ND (2017) Tobacco