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If anything, it's only gotten louder

It lessens immunity responses and prompts metalloproteinase MMP-1, an enzyme that explicitly debases collagen

Kaur, G., Pinkston, R., McLemore, B., Dorsey, W

It's reasonable to infer that similar mechanisms might be affecting dogs, whose neurophysiology shares many parallels with our own

The left hand panel of Figure 1 illustrates this
