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22 Exposure of alveolar macrophages (AMs) to a sublethal 0.5% EVC or nicotine-free ECVC (nfECVC) increases ROS production approximately 50-fold and significantly inhibits phagocytosis

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After quitting, the cilia gradually heal and return to their protective function, which dramatically improves mucus clearance and reduces the risk of infection

The slow, deliberate chewing action allows the tobacco to release nicotine gradually into the bloodstream