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Long-Term Risks of Smoking Sherm Long-term dangers of PCP include: Persistent anxiety, paranoia, or delusions Memory loss and cognitive impairment Depression and mood instability Increased risk of psychotic episodes, even when not using Brain damage due to neurotoxicity Physical dependence and withdrawal symptoms High potential for accidental injury or legal trouble Kidney damage and other organ failure Dangers of high doses, such as seizures, organ failure, and death Chronic use of PCP may permanently alter brain chemistry, making recovery difficult without professional intervention