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Glutamatergic and GABAergic Dysfunction A more recent hypothesis for SZ pathology involves glutamatergic dysfunction, involving the hypofunction of N -methyl-D-aspartate (NMDA) receptors of which glutamate, the major excitatory transmitter in the brain, binds (73, 74)

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Move it from one gum to another

Removing excess ash helps prevent any unpleasant flavors from mixing with the remaining tobacco when relit