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Several controlled laboratory studies of combustible tobacco cigarette smokers who have been acutely deprived of nicotine test the effects of e-cigarette use administration on nicotine withdrawal symptoms, combustible tobacco cigarette craving, and other factors believed to maintain smoking behavior

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But the FDA says that e-cigarettes have not been scientifically studied, so the amount of nicotine or other potentially harmful chemicals that users inhale and other potential health risks of using e-cigarettes remain uncertain