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Details regarding the assessment and coding of all included measures can be found in the sMethods (Supplement) and Supplementary Table S2

177 Some argue that having adults completely switch from cigarettes to ENDS can generally be viewed as positive for the public's health, given the morbidity and mortality associated with cigarette smoking

While anecdotal evidence may support this, a study carried out in 2005 showed no link between nicotine and increased bowel movements

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Neurodevelopmental models of schizophrenia in animals typically involve exposure of the neonate, either during gestation or the perinatal period, to adverse environmental insults such as maternal stress, hypoxia, malnutrition, or post-weaning social isolation that alter the brain development and cause behavioral deficits into adulthood [100102]