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This problem is particularly acute in the low-income countries where around 90% of the worlds tobacco is grown, as their less robust environmental regulations may permit the use of dangerous chemicals that are banned elsewhere

Because the addictive nature of nicotine is not uniform across all people, NIH estimates that as little as 0.5 mg of nicotine may be required to make cigarettes nonaddictive, perhaps even less, if the agency decides to include children in the study because they haven't built up a tolerance to nicotine yet

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