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Mine has frayed a bit, resembling suede more than a cigar in a few discrete locations, and the label is beginning to peel

To address how cigarette smoke affects macrophages mechanistically to provide a concise overview, we highlight the effect of cigarette smoke on three main pathways that influence macrophage phenotype and activity: the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) signalling pathway, the mitogen-activated protein kinase (MAPK) signalling pathway, and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway