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The four complexions sanguine, phlegmatic, choleric, and melancholic were believed to affect personality and physical characteristics in ways that related to the four elements, rendering bodily imbalance the root of other disorders.Footnote 20 Physicians who discouraged tobacco related the imbalance it caused to the natural humours of the body

That is insufficient data for a precise estimate in this report

Mathers C, Boerma T, Fat DM (2008)

What science does confirm is that synthetic nicotine avoids plant-based contaminants and pesticides , but the risks tied to nicotine itself still exist