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Other examples of synergistic subsiances include asbestos and cigarette smoking, which together cause nine times Inure lung cancer than would be expected if the effects of the two substances were merely added, and barbiturates and alcohol, which together can cause fatal respiratory depression at dose levels that would not be expected to kill if the two substances acted independently

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"Some Non-Heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures." IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol