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Chronic inhalation of ecigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice

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The inflammatory immune cells that infiltrate the epithelium, subepithelium, and glandular tissue in chronic bronchitis include the polymorphonuclear neutrophils (PMNs), macrophages, CD8-positive (CD8+) and CD4-positive (CD4+) T lymphocytes, and B cells that are part of the adaptive inflammatory immune process (Di Stefano et al