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The dose needed to mitigate symptoms can be estimated based on the patients average cigarette use

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When Phoenix accepted a Screen Actors Guild Award for his "Joker" role, he gave Ledger a heartfelt shout-out, and video footage (via Deadline) shows that he ended his acceptance speech by stating, "Really, I am standing here on the shoulders of my favorite actor, Heath Ledger." Buster Keaton influenced his role in Joker Part of what makes the performance of Joaquin Phoenix in "Joker" so impressive is how the actor was able to take a role played by other legendary actors like Heath Ledger and Jack Nicholson and truly make it unique.Yet Phoenix proved his unique take and nuanced performance worthy of adding another memorable Joker to the mix