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Contrast the chromosomes of a non-smoker ( left ) and a smoker ( right )
doi: 10.1016/j.jsbmb.2014.11.015
It has also been shown that mutp53 can disrupt the activity of VDR through various mechanisms, including proteinprotein interactions that modify VDRs localization, stability, or DNA-binding ability
Margo Lane (portrayed by Penelope Ann Miller) used one in The Shadow , as did Jade in Jonny Quest
This interesting work further reinforced the potential application of mutp53 reactivators as protective agents to delay early onset cancer in carriers of mutp53, namely induced by UVR
