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18 Nicotine acetylcholine receptors (nAChRs) are expressed on the surface of different cells, including immune and nerve cells

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A wide network of activated areas included cortical (motor cortex, insula, cingulate, amygdala) and sub-cortical (thalamus, putamen, globus pallidus, cerebellum) regions, with corresponding significant deactivations in ventral striatum and orbitofrontal cortex

1 Despite the fact that most adult smokers want to quit, fewer than one in ten smokers succeed in quitting smoking each year