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Over time, the risks of stroke, lung cancer, throat cancer, bladder cancer, and several other smoking-related diseases continue to decline

Chronic nicotine use dysregulates this system, increasing stress sensitivity and emotional instability over time. Additionally, Mendelian randomization studies have found causal evidence that smoking increases the risk of developing depression and even schizophrenia, rather than simply being a consequence of them. This supports the view that smoking may not only sustain but also exacerbate or even initiate mood disorders in vulnerable individuals

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But he persevered and the legendary career was to take its course