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VolkowNDWangGJFowlerJSLoganJGatleySJHitzemannRet alDecreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects

A pilot study described in Additional File 1 was conducted to inform key parameters of the present two-stage adaptive randomised controlled trial (RCT)
I had to stretch them out a bit

In other words, the fundamental cause is hormones

Drug use does not necessarily mean drug dependence