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Native Americans regard tobacco as a holy herb or Gods remedy used to treat a variety of diseases such as bronchitis, toothache, sore throat, pleuritis, jaundice, epilepsy, rhinitis, gastroenteritis, diarrhea, headache, otitis, whooping cough, syphilis, arthritis, dermatitis, colds, burns, abscess festering, and mosquito bites, and also applied for stopping bleeding, reducing fever, anti-fatigue, and whitening teeth (Sanchez-Ramos, 2020)