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Surgeon General concluded that users of chewing tobacco should know that chewing tobacco "is not a safe substitute for smoking cigarettes." Chewing tobacco contains nicotine, which is highly addictive, as well as several known cancer-causing chemicals

Similarly, in Nigeria, cigarette consumption has risen by 4.3% annually over the past five years, which is driven by urbanization and aggressive brand localization, as reported by the National Bureau of Statistics

Some other health effects of nicotine include: constricted blood vessels , which restricts the flow of blood throughout your body and may cause damage to your blood vessels higher blood pressure from constricted blood vessels increased risk of stroke and heart attack from higher blood pressure and damaged blood vessels increased risk of lung diseases , such as COPD and chronic bronchitis due to damage to lung tissue and airways DNA damage throughout your body that can increase the risk of many cancers, including cancer of the lungs, mouth, throat, bladder, kidneys, and cervix, as well as the blood (leukemia) persistent coughing from damage to the airways hearing loss from lack of blood flow to the ear vision loss and an increased risk of eye problems, such as glaucoma, macular degeneration, and cataracts loss of skin elasticity due to reduced blood flow, which can cause skin to age prematurely increased risk of miscarriage for pregnant women and a higher risk of sudden infant death syndrome (SIDS) in newborns whose mothers smoked Nicotine is an addictive stimulant thats found in cigarettes, cigars, and most vaping products

Napropamide is available in dry and liquid formulations and the normal use rate is approximately 1.1 kg ai/ha [19, 20]

Fourth, our analysis assumes that the relationships between smoking and health outcomes are similar across geographical regions and over time