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Varenicline works by binding to nicotine receptors in the body, partly turning them on to reduce withdrawal symptoms, but also blocking them from the nicotine in cigarettes and thus making smoking less pleasurable

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Stimulants can increase focus, feelings of euphoria, and energy

It is the most effective single-agent smoking cessation medication available, approximately tripling quit rates compared to willpower alone (around 2535% of users remain smoke-free at 12 months)

A study points out that higher nicotine levels, around 50 mg/ml, are needed to deliver nicotine more effectively and closely match the nicotine delivery of tobacco cigarettes (Farsalinos et al., 2015)