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10.3233/JAD-150664 31 DeochandC.TongM.AgarwalA

Tobacco was introduced to European society through early exploration and trade with the Americas in the late 15th and early 16th centuries

Equally important, these new products provide a platform from which the industry can position themselves as trying to help people quit

Strengths and limitations The main strengths of this study include the population-based cohort design, the large sample size of over 12 million live births, the detailed examination of the associations between the timing and intensity of maternal cigarette smoking and many congenital anomalies subtypes considered (including rare subtypes), the adjustment for several (but not all possible) covariates, and the sensitivity analyses used to confirm our findings

They also typically used chewing tobacco, cigarettes or vapes