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79 Studying patients with symptoms of UC and active intestinal autoimmune disease in 10 groups with nicotine treatment indicated side effects in 40% of the patients, and no improvement in histopathology, but 71% of patients showed relative improvement in clinical symptoms, 80 which may be due to the binding of nicotine to the 7-nAChR receptor, the development of an anti-inflammatory state, and inhibition of inflammatory cytokines secretion in the intestinal wall

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