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Murdin L, Schilder AG

When you combine these stimulants, youre doubling the vasoconstriction effect , caffeine amplifies adrenaline release while nicotine narrows your blood vessels, reducing cerebral oxygen delivery

Early observations supported that human monocytes exposed to specific flavoring chemicals such as cinnamaldehyde, vanillin, and pentane-dione, found in cinnamon, vanilla, and buttery flavor e-cigarettes, respectively, resulted in a significantly elevated proinflammatory profile [57, 58]

Using nicotine products during the adolescent years may be linked to a raised risk of addiction to other drugs in the future