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Drugs Alcohol Depen (2013) 131:28497.10.1016/j.drugalcdep.2012.12.021 18 VuCUSiddiquiJAWadensweilerPGayenJRAvolioEBandyopadhyayGKet alNicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggests dual opposing roles of the receptors in male mice

High dropout rates (61% lost to follow-up) raised questions about whether results apply to all former smokers or just those who remained in the study, with retained participants being older, less likely to be from England, more likely to be from an identified majority group, and having lower education compared to those lost to follow-up

46 FDA and legislators need to act quickly since more and more synthetic nicotine products reach the USA and international markets, threatening to invalidate the regulatory gains made by the currently ongoing PMTA review process

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Nicotine withdrawal disrupts the balance of neurotransmitters involved in mood regulation, contributing to emotional fluctuations