what is in cigarettes besides tobacco E-Cigarettes: Know the Health Risks Vapor Trail | Colorado Health
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The ideal ratio for a DIY smoke blend is: 2 tbsp base herb 1 tbsp supportive herb tbsp flavoring Crumble the dried leaves into small pieces, preferably into powder if using rolling paper

A standard carton of cigarettes contains 10 packs , giving you 200 cigarettes total in most markets including the US, UK, Canada, and EU
doi: 10.3390/ijerph13050465 Summary Keywords E-cigarettes, dopamine, glutamate, glutamine, GABA, serotonin Citation Alasmari F, Crotty Alexander LE, Hammad AM, Bojanowski CM, Moshensky A and Sari Y (2019) Effects of Chronic Inhalation of Electronic Cigarette Vapor Containing Nicotine on Neurotransmitters in the Frontal Cortex and Striatum of C57BL/6 Mice

Traditional brands usually exist for decades, sometimes generations, without major disruption
I think there is much more of this story to be told and think a second and possibly even a third season is likely