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These include species such as superoxide (O 2 ), hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), and peroxynitrite/peroxynitrous acid (ONOO /ONOOH)

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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The knockdown of p53 with a specific short interfering (si) RNA or pifithrin- recovered mitochondrial clearance in H-Ras 12V expressing wild-type (WT) MEFs, but did not affect any further decreases in p53 / MEFs (Fig
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