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Similarly, Antoun et al (46) assessed DNA methylation in cord blood from 1,040 newborns and found that alterations in specific genes associated with birth weight could be traced to maternal smoking, pregnancy-induced hypertension and folate status during gestation

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Excessive levels of glucose and free fatty acids induce stress in insulin-sensitive tissues resulting in the release of several cytokines and chemokines including CRP, fibrinogen, plasminogen activator inhibitor (PAI), IL-1, TNF-, CC-chemokine ligand 2 (CCL2), CCL3, CXC-chemokine ligand 8 [55, 56]