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Chronic gastrointestinal diseases can also cause vomiting, diarrhea and weight loss in dogs, and may also cause the digestive system to be damaged or altered, which results in less vitamin B12 absorption

Fluorescence spectroscopy was crucial for discovery of protein conformational breathing, which was the foundation of the shift of the traditional view of proteins as rigid, static structures to a more accurate model of flexible, fluctuating molecules essential for biological function

Scientifically my bet would be that for some tests it matters and for some not

Thrombocytosis: Dangerous Increase in Blood Platelets B12 replacement therapy can trigger significant thrombocytosis (excessive production of platelets, the blood cells responsible for clotting)
A pain in my lower back while getting out of bed will make me wonder if I have relapsed