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Experiments on cirrhotic GF mice and conventional mice have shown that ammonia level in cirrhotic animals is higher than in non-cirrhotic GF ones and similarly in conventional mice, but neuro-inflammation and microglial activation have only been seen in the conventional cirrhotic mice (104)
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The peptide upregulates vascular endothelial growth factor (VEGF), a primary signaling protein responsible for triggering new capillary growth in damaged tissue
La grande maggioranza dei dati proviene da studi in vivo condotti su modelli murini e di ratto, nonch da esperimenti in vitro su colture cellulari
doi: 10.1053/j.gastro.2024.12.011
