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Figure 3A shows that LPS markedly induced the phosphorylation of NF-kB p65 at Ser536 in RAW 264.7 cells, while the treatment with GHK-Cu (1, 5, and 10 M) inhibited the LPS-stimulated phosphorylation of NF-kB p65 at Ser536

Rats tolerated doses far exceeding those used therapeutically without mortality or obvious adverse effects

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Vitamin B12 injections may not be suitable for people who have a history of: allergic reaction or sensitivity to cobalt or vitamin B12 Leber disease kidney disease or impaired kidney function Also, vitamin B12 injections may not be necessary for people without a deficiency

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